Synthesis of platelet-activating factor and its receptor expression in Kupffer cells in rat carbon tetrachloride-induced cirrhosis

Figure 1 Effect of ET-1 on PAF synthesis in cultured activated Kupffer cells. Kupffer cells from control and cirrhotic rats were cultured and stimulated with increasing concentrations of ET-1 for 15 min in serum-free medium. Cell-associated and released PAF levels were determined as explained in the Methods section. Each point represents an average of triplicate values ± SEM from a representative of two experiments. ^aP < 0.05 and ^bP < 0.01 vs vehicle; ^cP < 0.05 and ^dP < 0.01 vs control.