Peripheral corticotropin releasing hormone mediates post-inflammatory visceral hypersensitivity in rats

Figure 1 Colitis-induced changes in colonic mucosal MPO activity (A), plasma level of CRH (B), and visceral nociceptive AWR (C). In panel A and B, the upper and lower whiskers indicate the maximum and minimum values, respectively. Box lines represent the 25th (bottom), 50th (middle) and 75th (top) percentile value; (C) The area under the curve (AUC) calculated from the stimulus-response plot is illustrated as a bar graph on the right side. ^aP < 0.05, ^bP < 0.01 vs control by MWU test after KW test (P < 0.01).