Diagnosis and management of microscopic colitis

Table 2 Data from four randomized, placebo-controlled trials of oral budesonide in CC and LC

Author year	Number of cases	Dosage	Clinical response budesonide vs placebo	Histological response budesonide vs placebo	Adverse events
Collagenous colitis
Baert et al[91] 2002	28	9 mg/d Budenofalk 8 wk	Improvement: 8/14 vs 3/14 (P = 0.05)	Reduction of lamina propria inflammation in 9/13 vs 4/12 (P < 0.001) No difference in collagen layer	Mild No difference between treatment groups
Miehlke et al[93] 2002	45	9 mg/d Entocort 6 wk	Remission: 15/23 vs 0/22 (P < 0.0001)	Improvement in 17/23 vs 5/22 (P < 0.01) No difference in collagen layer	Mild 38% vs 12% P = 0.052
Bonderup et al[92] 2003	20	9 mg/d Entocort 8 wk	Response: 10/10 vs 2/10 (P < 0.001)	Reduction of overall inflammation (P < 0.01) and of collagen layer in sigmoid colon (P < 0.02)	None
Lymphocytic colitis
Miehlke et al[95] 2007	41	9 mg/d Budenofalk 6 wk	Remission: 18/21 vs 8/20 (P = 0.004)	Response in 11/15 vs 4/12 (P = 0.04)	Mild No difference between treatment groups