Role of ErbB family receptor tyrosine kinases in intrahepatic cholangiocarcinoma

Figure 2 ErbB2 expression in human intrahepatic cholangiocarcinoma. A: Differences in overall reported frequencies of archival human intrahepatic cholangiocarcinoma specimens scored as being immunohistochemically- positive for ErbB2 expression using non-uniform experimental methods and criteria; B: Range of reported frequencies of archival human intrahepatic cholangiocarcinomas scored as being moderately-to-strongly positive (+2 to +3) for ErbB2 immunoreactivity following antigen unmasking by heating of tissue specimens in citric acid buffer, pH 6.0. Number in () = number of cases analyzed; number in [] = reference number; In A, ¹refers to Japanese cases analyzed; ²refers to Thai cases analyzed.