Noninvasive assessment of liver fibrosis with combined serum aminotransferase/platelet ratio index and hyaluronic acid in patients with chronic hepatitis B

Table 3 Sensitivity, specificity, PPV, and NPV of APRI ≤ 1.5 in combination with different HA cut-off points for the detection of liver fibrosis (stages 0-1) in CHB patients

	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	+LR	-LR
APRI < 1. 5	35.3	81.6	41.3	82.2	1.9	0.79
+HA < 300	45.7	86.2	44.6	83.1	3.3	0.63
+HA < 250	42.8	83.2	42.8	81.3	2.5	0.69
+HA < 200	38.5	80.8	40.8	80.3	2.0	0.76
+HA < 150	31.7	78.8	37.1	77.7	1.5	0.87