Noninvasive assessment of liver fibrosis with combined serum aminotransferase/platelet ratio index and hyaluronic acid in patients with chronic hepatitis B

Table 2 Sensitivity, specificity, PPV, and NPV of APRI > 1.5 in combination with different HA cut-off points for the detection of liver fibrosis (stages 2-4) in CHB patients

	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	+LR	-LR
APRI ≥ 1.5	44.7	84.3	41.3	84.7	2.80	0.66
+HA ≥ 150	46.6	95.6	88.6	89.5	10.6	0.56
+HA ≥ 200	46.8	97.8	90.2	89.9	21.3	0.54
+HA ≥ 250	47.3	98.7	93.2	90.2	36.4	0.53
+HA ≥ 300	45.3	98.9	93.7	91.3	41.2	0.55