Aquaporins: Their role in cholestatic liver disease

doi:10.3748/wjg.14.7059

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Dec 14, 2008 (publication date) through Feb 1, 2025

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Dec 14, 2008; 14(46): 7059-7067
Published online Dec 14, 2008. doi: 10.3748/wjg.14.7059

Table 2 Molecular and functional expression of AQPs in cholestasis

Experimental model	AQP8			AQP9			Ref.
Experimental model	Protein	mRNA	CPM P_f	Protein	mRNA	BLM P_f	Ref.
Obstructive cholestasis
BDL	↓↓	↑	ND	↓↓↓	↓	↓	[57,58]
Intracellular cholestasis
EE-induced cholestasis	↓↓↓	↑	↓	↔	ND	ND	[59]
LPS-induced cholestasis	↓↓↓	↑	↓	↔	ND	ND	[64]
CLP-induced cholestasis	↓↓↓	ND	ND	↔	ND	ND	[66]

Arrows depict significant protein and mRNA changes in treated rats compared with controls: ↑, increased; ↓, decreased; ↔, without change. ND: Not determined; P_f: Osmotic membrane water permeability; CPM: Canalicular plasma membrane; BLM: Basolateral plasma membrane; BDL: Bile duct ligation; EE: 17α-ethinylestradiol; LPS: Lipopolysaccharide; CLP: Cecal ligation and puncture.

Citation: Lehmann GL, Larocca MC, Soria LR, Marinelli RA. Aquaporins: Their role in cholestatic liver disease. World J Gastroenterol 2008; 14(46): 7059-7067
URL: https://www.wjgnet.com/1007-9327/full/v14/i46/7059.htm
DOI: https://dx.doi.org/10.3748/wjg.14.7059