Effects of Wy14643 on hepatic ischemia reperfusion injury in rats

Figure 2 Ultrastructural alterations of liver tissue. A: Sham group. Normal appearance of mitochondrion, rough endoplasmic reticulum and nucleus structure; B: I/R group. Mitochondrion swelled significantly with vacuolar degeneration and mitochondrial crista destruction, marked decrease of rough endoplasmic reticulum and nucleus structure destruction; C: Wy14643 group (1 mg/kg). Mitochondrion swelled moderately, with mitochondrial crista interruption and vacuolar degeneration, increase of rough endoplasmic reticulum and nucleus structure destruction; D: Wy14643 group (5 mg/kg). Mitochondrion swelled mildly, with rough endoplasmic reticulu and normal nucleus structure; E: Wy14643 group (10 mg/kg). Normal appearance of mitochondrion, rough endoplasmic reticulum and nucleus structure.