Interaction of methylenetetrahydrofolate reductase C677T, cytochrome P4502E1 polymorphism and environment factors in esophageal cancer in Kazakh population

Table 4 Interaction between CYP4502E1 RsaI 677 and alcohol drinking, safety drinking water in EC

		CYP4502E1 rsaI genotype	Case (n)	Control (n)	χ2	P	OR (95% CI)
Alcohol drinking1	Never	C1/C2 + C2/C2	12	70	-	-	1.00
	Yes	C1/C2 + C2/C2	14	42	2.34	0.126	1.94 (0.82-4.60)
	Never	C1/C1	38	82	7.59	0.006	2.70 (1.31-5.57)
	Yes	C1/C1	56	46	31.64	0.000	7.10 (3.44-14.68)
Safe drinking water2	Yes	C1/C2 + C2/C2	9	78	-	-	1.00
	No	C1/C2 + C2/C2	17	34	11.12	0.001	4.33 (1.76-10.69)
	Yes	C1/C1	34	85	10.11	0.001	3.47 (1.56-7.69)
	No	C1/C1	60	43	46.80	0.000	12.09 (5.47-26.74)

SIM: Synergic index of multiplication; SIM1 = 7.10/(1.94 × 2.70) = 1.36, RERI¹ = 7.10 - (1.94 + 2.70) + 1 = 3.46, API¹ = [7.10 - (1.94 + 2.70) + 1]/7.10 = 48.73%; SIA² = 12.09/(4.33 + 3.47 - 1.00) = 1.78, RERI² = 12.09 - (4.33 + 3.47) + 1 = 5.29, API² = [12.09 - (4.33 + 3.47) + 1]/12.09 = 43.76%.