Interaction of methylenetetrahydrofolate reductase C677T, cytochrome P4502E1 polymorphism and environment factors in esophageal cancer in Kazakh population

Table 2 Genotype risk assessment of EC in cases and controls

Genotype	Case n (%)	Control n (%)	P1	OR (95% CI)1
MTHFR677
C/C	60 (50.00)	170 (70.83)	-	1.00
C/T	53 (44.17)	59 (24.59)	0.000	2.69 (1.63-4.44)
T/T	7 (5.83)	11 (4.58)	0.144	2.15 (0.77-5.98)
C/C	60 (50.00)	170 (70.83)	-	1.00
C/T + T/T	60 (50.00)	70 (29.17)	0.000	2.62 (1.61-4.28)
CYP2E1 RsaI
C1/C1	94 (78.33)	128 (53.33)	-	1.00
C1/C2	23 (19.17)	90 (37.50)	0.000	0.37 (0.22-0.62)
C2/C2	3 (2.50)	22 (9.17)	0.009	0.19 (0.05-0.66)
C1/C2 + C2/C2	26 (21.67)	112 (46.67)	-	1.00
C1/C1	94 (78.33)	128 (53.33)	0.000	3.00 (1.82-4.96)

¹ORs, 95% CIs and P values were calculated in a conditional logistic regression model.