Gene expression profiling: Canonical molecular changes and clinicopathological features in sporadic colorectal cancers

Table 4 Class prediction accuracies (%) relative to molecular changes and clinicopathological features

Parameters	Genes1	CCP	DLDA	1-NN	3-NN	NC	SVM	BCCP
Tumor location	620	85	86	92	90	86	94	94
Synchronous adenoma	12	58	60	64	63	57	67	65
Tumor stage	22	62	58	58	60	61	54	60
APC mutations	12	72	72	57	72	67	73	67
LVN invasion	27	70	69	57	60	68	64	68
MMR defects	44	76	77	82	82	76	81	83
p53 alterations	8	65	70	61	73	66	72	79
RAF-mediated alterations	3	36	35	43	51	36	42	69
Wnt-activated alterations	9	54	54	61	61	58	49	54

¹Number of classifier genes. CCP: Compound covariate predictor; DLDA: Diagonal linear discriminant analysis; 1-NN: One nearest-neighbor; 3-NN: Three nearest-neighbor; NC: Nearest centroid; SVM: Support vector machine; BCCP: Bayesian compound covariate predictor; LVN: Lymphovascular or neural.