Gene expression profiling: Canonical molecular changes and clinicopathological features in sporadic colorectal cancers

Table 3 Differential gene expression associated with molecular changes and clinicopathological features¹

Parameters	Symbol	Name	Log2 fold changes	Unadjusted P
APC mutations	CDH7	Cadherin 7, type 2	0.419885	0.00033
	DYRK1A	DS tyr-(Y)-phosphorylation regulated kinase 1A	0.326912	0.000343
	SLC19A2	Solute carrier family 19 member 2	-0.48574	0.000427
	PISD	Phosphatidylserine decarboxylase	0.272127	0.000545
	NDUFC1	NADH dehydrogenase 1, subcomplex unknown	0.539581	0.000572
Wnt-activated alterations	PRAF2	PRA1 domain family, member 2	0.620619	0.000205
	FOXF1	Forkhead box F1	-0.93359	0.000524
	CD99L2	CD99 molecule-like 2	0.753489	0.000772
MMR defects	HMGB1	High-mobility group box 1	-0.38141	3.74E-06
	MT1X	Metallothionein 1X	0.965429	0.000252
	MT1A	Metallothionein 1A	1.17894	0.000351
	SUGT1	SGT1, G2 allele of SKP1 (S. cerevisiae)	-0.34799	0.00039
	VTI1B	Vesicle transport with t-SNAREs homolog 1B (yeast)	-0.28513	0.000435
	SST	Somatostatin	1.24407	0.000564
	TDG	Thymine-DNA glycosylase	0.479829	0.000946
RAF-mediated alterations	RAB22A	RAB22A, member RAS oncogene family	-0.36017	0.000289
	PPP1R13L	Protein phosphatase 1, regulatory subunit 13 like	0.823379	0.000614
	CAST	Calpastatin	0.285773	0.000872
Altered p53 expression	HLA-F	Major histocompatibility complex, class I, F	-0.55645	0.000429
	XRCC3	XRCC in Chinese hamster cells 3	-0.26678	0.000588
	CCDC24	Coiled-coil domain containing 24	-0.28995	0.000996
Crossover2	NID2	Nidogen 2 (osteonidogen)	0.938223	0.000214
	EGLN3	egl nine homolog 3 (C. elegans)	0.740933	0.000375
	ITIH1	Inter-alpha (globulin) inhibitor H1	-0.34777	0.0004
	CFH	Complement factor H	-0.33826	0.000542
	ABI3BP	ABI gene family, member 3 binding protein	-0.82558	0.000637
	NIBP	NIK and IKK binding protein	0.649949	0.000688
	SPRR3	Small praline-rich protein 3	0.99738	0.000946
AJCC stage3	PNPT1	Polyribonucleotide nucleotidyltransferase 1	0.716381	4.94E-06
	BAI2	Brain-specific angiogenesis inhibitor 2	0.545369	1.57E-05
	ADCY1	Adenylate cyclase 1 (brain)	-0.43437	1.97E-05
	VEGFC	Vascular endothelial growth factor C	0.329341	9.11E-05
	ATAD3B	ATPase family, AAA domain containing 3B	-0.40978	0.000108
	CAP1	CAP, adenylate cyclase-associated protein 1 (yeast)	-0.66905	0.000405
	RPS6KA6	Ribosomal protein S6 kinase, 90kDa, polypeptide 6	0.301665	0.000586
	FGF5	Fibroblast growth factor 5	0.464162	0.000701
LVN invasion	MMP12	Matrix metallopeptidase 12 (macrophage elastase)	-0.69015	7.76E-05
	RAP1GDS1	RAP1, GTP-GDP dissociation stimulator 1	-0.60949	9.63E-05
	STOML1	Stomatin (EPB72)-like 1	-0.39407	0.000255
	CCL16	Chemokine (C-C motif) ligand 16	0.475838	0.000542
	NOTCH3	Notch homolog 3 (Drosophila)	0.592567	0.000679
	DHPS	Deoxyhypusine synthase	-0.33131	0.000965
Synchronous adenoma	PARP2	Poly (ADP-ribose) polymerase family, member 2	0.573461	6.00E-05
	MRPL21	Mitochondrial ribosomal protein L21	0.243204	0.000149
	MRPL16	Mitochondrial ribosomal protein L16	0.267004	0.000432
	MKKS	McKusick-Kaufman syndrome	0.439584	0.000447
	LHX2	LIM homeobox 2	0.663108	0.000782

¹Differential gene expression in tumor tissues compared to normal epithelia was examined in terms of molecular changes and clinicopathological features, as was considered to be significant when P < 0.001;

²When a tumor carried both APC/Wnt-mediated alterations and MMR defects or RAF-mediated alterations;

³According to the American Joint Committee on Cancer (6th ed., 2001).