Clear cell adenocarcinoma of the colon is a unique morphological variant of intestinal carcinoma: Case report with molecular analysis

Figure 1 HE and KRAS sequencing. A: The 0.9 cm diameter lesion at the hepatic flexure was a CCA with surface erosion, focal invasion of the muscularis propria, and an abrupt transition from the normal adjacent mucosa (HE, × 4); B: Clear cells with a solid growth on the surface and budding with single-cell growth at the periphery; no conventional adenoma was seen near to the CCA (HE, × 2); C: Strong β-catenin nuclear positivity (× 20); D: Nuclear hMLH1 positivity (× 40); E: Nuclear hMSH2 positivity (× 40); F: KRAS sequencing revealed the point mutation GGT>GTT that leads to the activating aminoacid substitution Gly12Val.