Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice

Figure 3 PCNA overexpression in colorectal tumor cells of KO mice. Immunohistochemical staining for PCNA in colorectal tumors using rat anti-mouse PCNA monoclonal antibody. Cells with strongly stained nuclei were considered positive for PCNA. A: Representative section of a colorectal tumor in a WT mouse and a KO mouse (× 200); B: PCNA labeling index in colorectal tumors. WT mice (n = 9), KO mice (n = 11) (^bP < 0.01, Student’s t-test). Results are mean ± SE.