Adiponectin deficiency enhances colorectal carcinogenesis and liver tumor formation induced by azoxymethane in mice

Figure 1 Enhanced AOM-induced colorectal carcinogenesis in KO mice. A: Changes in percentage of body weight. P < 0.01, between WT + saline (n = 9) and WT + AOM (n = 23). P < 0.001, between KO + saline (n = 13) and KO + AOM (n = 24); B: Representative pictures of the colorectal tumors arising in WT and KO mice after AOM treatment; C: Tumor incidence is expressed as the ratio of mice with tumor/total number of mice (NS: Not statistically significant; χ² test); D: Tumor frequency. WT, n = 9; KO, n = 9 (^aP < 0.05, Student’s t-test); E: Tumor size. WT, n = 9; KO, n = 19 (^cP < 0.05, Student’s t-test). Results are presented as mean ± SE.