Ste20-related proline/alanine-rich kinase: A novel regulator of intestinal inflammation

Figure 2 Ste20 kinases participate in inflammation. Ste20 kinases that function as an MAP4K can activate MAP3K, MAP2K and MAPK, leading to the inflammatory functions. This model adapted from the model presented in http://www.cellsignal.com/pathways/map-kinase.jsp. MAPK: Mitogen-activated protein kinase. GPCR: G-protein coupled receptor; PAK: p21 activated kinase; GCK: Germinal central kinase; MLK: Multiple lineage kinase; TAK: Tat-associated kinase; DLK: Dual leucine zipper-bearing kinase; MEK: MAPK/Erk kinase; MEKK: MEK kinase; ASK: Aspartate kinase; MKK: MAPK kinase; Erk: Extracellular signal-regulated kinase; SAPK: Stress-activated protein kinase; JNK: Jun-amino-terminal kinase.