Liver stiffness in the hepatitis B virus carrier: A non-invasive marker of liver disease influenced by the pattern of transaminases

Table 6 Diagnostic performance of FS for identification of fibrosis ≥ S3 and cirrhosis by using the cut-offs of 7.5 kPa and 11.8 kPa

	Fibrosis stage≥S3		Fibrosis S5-S6/US cirrhosis
	IC + UT CHB	T CHB	IC + UT CHB	T CHB
Sensitivity (%)	93.9	78.8	86.5	54.2
Specificity (%)	88.5	71.4	96.3	90.5
Positive predictive value (%)	76.7	92.9	86.5	94.1
Negative predictive value (%)	97.3	41.7	96.3	41.3
Diagnostic accuracy (%)	90.1	77.5	94.2	63.8
Likelihood ratio for pos. test	8.18	2.76	23.18	5.69
Likelihood ratio for neg. test	0.07	0.30	0.14	0.51

IC + UT CHB: Inactive carriers + untreated CHB (171 patients); T CHB: Treated chronic hepatitis B (80 patients).