Decreased phagocytic activity of Kupffer cells in a rat nonalcoholic steatohepatitis model

Figure 4 A: Fluorescence micrographs (× 1000). In the control group, there was no uptake of multiple latex beads (phagocytic activity) by the triangular shaped Kupffer cells, whereas the latex bead uptake was reduced in the NASH groups; B: Phagocytosis of FITC-latex beads by Kupffer cells in vivo (× 100). Decreased latex bead uptake was seen in the NASH groups compared with the control group; C: When compared with the control group, fluorescence was reduced to approximately 50% in the 1-wk group, and to 30% in the 2-wk group, but there was no further decrease after 3 wk (n = 5). ^cP < 0.001.