Fibrinogen-like protein 2/fibroleukin prothrombinase contributes to tumor hypercoagulability via IL-2 and IFN-γ

Figure 6 Increase of procoagulant activity (PCA) in HUVEC and THP-1 cells after IFN-γ and IL-2 stimulation dependent on FII but not FX. HUVEC and THP-1 cells received IFN-γ (200 U/mL) and IL-2 (100 U/mL) for 12 h and the PCA was assayed. IFN-γ and IL-2 increased PCA and this effect is preserved in FX poor plasma whereas is absent in FII poor plasma. ^aP = 0.0026, vs HUVEC alone; ^bP = 0.0037, vs THP-1 alone; ^cP = 0.0002, FII deficient plasma group vs normal plasma group or FX deficient plasma group; ^dP = 0.0001, FII deficient plasma group vs normal plasma group or FX deficient plasma group.