Therapy with bone marrow cells reduces liver alterations in mice chronically infected by Schistosoma mansoni

Figure 4 Reduction of fibrosis and granuloma area after BMC therapy. Mice infected with S.mansoni and treated with saline or BMC by intralobular (A and C) or iv B and D routes were sacrificed 2 mo after treatment. Liver sections sampled randomly and stained with Sirius red-Fast green were examined by optical microscopy. Images were digitalized and analyzed by morphometry. The percentage of fibrosis (A and B) and the area of periocular granulomas (C and D) were evaluated. Data were represented graphically as mean ± SE of 5-14 animals per group. ^aP < 0.05 and ^bP < 0.01 compared to saline-treated group.