Depletion of CD4+CD25+ regulatory T cells can promote local immunity to suppress tumor growth in benzo[a]pyrene-induced forestomach carcinoma

Figure 2 Histology of forestomach carcinoma in mice. Mice were sacrificed at wk 16 (A-C) and wk 32 (D-F) with their stomachs excised. The number of squamous cell carcinomas was increased in BaP + IgG-treated (B, E) and BaP + PC61-treated mice (C, F). However, there was a significant infiltration of lymphocytes and granulocytes into tumors of BaP + PC61-treated mice (F, inset). A and D: control mice; B and E: BaP + IgG-treated mice; C and F: BaP + PC61-treated mice.