Depletion of CD4+CD25+ regulatory T cells can promote local immunity to suppress tumor growth in benzo[a]pyrene-induced forestomach carcinoma

doi:10.3748/wjg.14.5797

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Oct 14, 2008 (publication date) through Nov 18, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Esophageal Cancer

World J Gastroenterol. Oct 14, 2008; 14(38): 5797-5809
Published online Oct 14, 2008. doi: 10.3748/wjg.14.5797

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Figure 1 Forestomach tumors (arrow) in BaP-treated mice with/without depletion of Tregs. Mice were sacrificed at wk 16 (A-C) and wk 32 (D-F) after the first administration of benzo[a]pyrene (BaP) in control mice (A and D), BaP + IgG-treated mice (B and E), and BaP + PC61-treated mice (C and F). After depletion of Tregs by PC61, the size and volume of forestomach carcinoma reduced significantly.

Citation: Chen YL, Fang JH, Lai MD, Shan YS. Depletion of CD4⁺CD25⁺ regulatory T cells can promote local immunity to suppress tumor growth in benzo[a]pyrene-induced forestomach carcinoma. World J Gastroenterol 2008; 14(38): 5797-5809
URL: https://www.wjgnet.com/1007-9327/full/v14/i38/5797.htm
DOI: https://dx.doi.org/10.3748/wjg.14.5797