Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis

Table 2 Clinical characteristics¹

	Total	HBV-group	HCV-group	P
Number (n)	8200	2050	6150
Age (yr)	51.8 ± 9.0	51.7 ± 8.7	51.8 ± 9.1	1
Sex (male, %)	77.8% (6380)	77.8% (1595)	77.8% (4785)	1
Liver cirrhosis2	20.2% (1659)	18.5% (379)	20.8% (1280)	< 0.001
Total alcohol intake of > 200 kg3	23.0% (1490/6465)	17.4% (253/1450)	24.7% (1237/5015)	< 0.001
Smoking index of > 203	27.9% (1680/6032)	23.5% (293/1246)	29.0% (1387/4786)	< 0.001
AST (IU/L)	75.9 ± 124.5	82.9 ± 138.2	73.8 ± 120.3	< 0.001
ALT (IU/L)	104.2 ± 107.5	124.4 ± 119.9	98.5 ± 103.6	< 0.001
Total bilirubin (mg/dL)	0.83 ± 0.94	0.98 ± 0.85	0.81 ± 0.77	< 0.001
γGTP (IU/L)	74.0 ± 106.2	77.1 ± 128.7	73.2 ± 99.8	0.951
Platelet count (x 104/mm3)	19.3 ± 18.7	19.1 ± 14.4	19.4 ± 19.7	0.725

¹Data are percent (number of patients) or mean ± SD;

²The 1594 (77.8%) out of 2050 in HBV-group and 5232 (85.1%) of 6150 in HCV-group were diagnosed by laparoscopy and/or liver biopsy. The breakdown of histological staging in HCV-group was as follows: stage 1, 2707; stage 2, 1188; stage 3, 300; stage 4 (liver cirrhosis), 1037. The outbreak of histological staging in HBV-group was as follows: stage 1, 705; stage 2, 439; stage 3, 157; stage 4 (liver cirrhosis), 293;

³Smoking index = (package/d) × yr; Total alcohol intake and smoking index indicate the sum of before and after first consultation.