Virologic characteristics of hepatitis B virus in patients infected via maternal-fetal transmission

Figure 2 Nucleotide sequences of the 27 HBV/C isolates and 50 other complete genome sequences of genotype C [light gray, Mother: 602 (1 d); Gray, 6022 (6 mo); Dark gray, Son: 602-S; Sequences: Gray (deletion), black (substitution of nucleotides)]. Compared with the 50 complete genome sequences of genotype C, nucleotide positions at 105T, 346C, 855C,861T, 930G, 951T, 1110T, 1341C, 1972C, 2215C, 2246C,2480T and 3102A were specific for the 27 samples. 14 clones of the mother had an 18bp deletion from start codon; 5 clones of the son had a 17nt deletion from nt2330; 1762T/1764A double mutations were found in all clones of the mother, but none in the sequenced clones of the son. Nucleotides A1762A and G1764A double mutation comprised 54.5% of the total genotype C (42/77).