Severe thrombocytopenia before liver transplantation is associated with delayed recovery of thrombocytopenia regardless of donor type

Table 2 Univariate and multivariate analysis of clinical factors associated with sustained thrombocytopenia (< 100 000/μL) at 12 mo after the operation

	Sustained thrombocytopenia1		Univariate analysis	Multivariate analysis
	Absent (n = 144)	Present (n = 56)	P	P	OR (95% CI)
Age at transplant (yr)	48.8 ± 7.9	48.6 ± 7.3	ns
Gender			ns
Male	108	40
Female	36	16
Cirrhosis complication, pretransplant			ns
Present	110	44
Absent	34	12
MELD, pretransplant (LDLT)			ns
> 25	20	6
≤ 25	91	38
Child classification, preptranplant			ns
C	75	34
A and B	69	22
Platelet count, pretransplanta			< 0.001	< 0.001	6.314 (2.828-14.095)
Group 1 and 2	56	45
Group 3 and 4	88	11
Spleen volume, pretransplanta			< 0.001	0.004	8.464 (2.001-35.810)
> 2000 mm	3	10
≤ 2000 mm3	124	41
Donor type			ns
LDLT	111	44
CDLT	33	12
Acute rejection			ns
Present	21	5
Absent	123	51
Mycophenolate mofetil use			ns
Yes	44	13
No	100	43
Biliary complication, posttransplant			ns
Present	36	16
Absent	108	40
Portal flow disturbance, posttransplant			ns
Present	3	4
Absent	141	52

^aP < 0.05.

¹Included the patients who survived more than 12 mo. OR: Odds ratio; CI: Confidence interval; HCC: Hepatocellular carcinoma; MELD: Model for end-stage liver disease; ns: Non-specific (P > 0.05).