Physiology of bile secretion

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Oct 7, 2008 (publication date) through Nov 28, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2008; 14(37): 5641-5649
Published online Oct 7, 2008. doi: 10.3748/wjg.14.5641

Table 2 Membrane transporters in cholangiocytes: Abbreviations and function

Abbreviation	Function
Basolateral membrane
NDCBE/SLC4A8¹	Na⁺-dependent Cl^-/HCO₃^- exchanger:
	Import HCO₃^- and Na⁺, Export H⁺ and Cl^-
NHE/SLC9¹	Na⁺/H⁺ exchanger: Acid extruder
AQP4¹	Water channel
tASBT/SLC10A2	Export BAs and Na⁺
SK2	Potassium channel, potassium efflux
SLC12A2	Import Na⁺-K⁺-2Cl^-
MRP3/ABCC3	Export OA^- conjugates, GSH
MRP4/ABCC4	Export BAs, GSH
Apical membrane
AE2/SLC4A2¹	Cl^-/HCO₃^- anion exchanger: Acid loader
CFTR¹	Cl^- channel: Export chloride
AQP1¹	Water channel
NBCe/NBC4/SLC4A5	Na⁺-HCO₃^- symporter: Acid extruder
ASBT/SLC10A2	BAs-Na⁺, symport: Uptake of BAs and Na⁺

¹Transporters relevant to bile flow under physiological basal conditions.

Citation: Esteller A. Physiology of bile secretion. World J Gastroenterol 2008; 14(37): 5641-5649
URL: https://www.wjgnet.com/1007-9327/full/v14/i37/5641.htm
DOI: https://dx.doi.org/10.3748/wjg.14.5641