Physiology of bile secretion

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Oct 7, 2008 (publication date) through Nov 2, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Oct 7, 2008; 14(37): 5641-5649
Published online Oct 7, 2008. doi: 10.3748/wjg.14.5641

Table 1 Membrane transporters in hepatocytes

Abbreviation	Function
Basolateral membrane (sinusoidal)
NTCP/SLC10A1¹	Takes up BAs
OATP/SLC21A¹	Takes up BAs and OA^- and exports BAs, GSH, HCO₃^-
MRP3/ABCC3	Export OA^- conjugates, GSH
MRP4/ABCC4	Export BAs, GSH
OSTa /OSTb	Organic solute transporter: Exports BAs
NBC4c/SLC4A5¹	Na⁺-HCO₃^- symporter, acid extruder
NHE1/SLC9A1¹	Na⁺/H⁺ exchanger, acid extruder
SK2	Potassium channel, potassium efflux
SLC12A2	Na⁺-K⁺-Cl^- symporter: Sodium, potassium, chloride uptake
Apical membrane (canalicular)
BSEP/ABCB11¹, formerly SPGE	Bile salt export pump
MRP2/ABCC2¹, formerly cMOAT	Export non BAs OA^-, GSH
MDR1	Efflux of lipofilic cations
MDR3/ABCB4	Phospholipid flipase
ABCG5/ABCG8	Export sterols
AE2/SLC4A2¹	Cl^-/HCO₃^- anion exchanger: Acid loader
Cl- channel¹	Export chloride
AQP8¹	Water channel
NHE3/SLC9A3¹	Na⁺/H⁺ exchanger: Acid extruder

¹Transporters relevant to bile flow under physiological basal conditions.

Citation: Esteller A. Physiology of bile secretion. World J Gastroenterol 2008; 14(37): 5641-5649
URL: https://www.wjgnet.com/1007-9327/full/v14/i37/5641.htm
DOI: https://dx.doi.org/10.3748/wjg.14.5641