Are we giving azathioprine too late? The case for early immunomodulation in inflammatory bowel disease

doi:10.3748/wjg.14.5512

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Sep 28, 2008 (publication date) through Nov 6, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastroenterol. Sep 28, 2008; 14(36): 5512-5518
Published online Sep 28, 2008. doi: 10.3748/wjg.14.5512

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Figure 2 Metabolism of azathioprine (AZA): AZA is converted to 6-mercaptopurine (6-MP). 6-MP by thiopurine methyltransferase (TPMT) and xantino oxidase (XO) in inactive metabolites, but phosphoriboxyltransferase (HPRT), inosine monophosphate dehydrogenase (IMPDH) and guanosine monophosphate synthetase (GMPS) catalize the synthesis of active 6-thioguanine nucleotides (6-TGNs).

Citation: Etchevers MJ, Aceituno M, Sans M. Are we giving azathioprine too late? The case for early immunomodulation in inflammatory bowel disease. World J Gastroenterol 2008; 14(36): 5512-5518
URL: https://www.wjgnet.com/1007-9327/full/v14/i36/5512.htm
DOI: https://dx.doi.org/10.3748/wjg.14.5512