Relationship between nm23H1 genetic instability and clinical pathological characteristics in Chinese digestive system cancer patients

Table 6 Relationship between clinical pathological parameters and nm23H1 genetic instability in gallbladder cancer

Clinical pathological factors	Cases	MSI + (%)	LOH + (%)	nm23H1 + (%)	nm23H1 expression intensity (mean ± SD)
Differentiation degree	47	11 (22.40)	9 (19.14)	22 (46.81)	25.96 ± 2.73
High differentiation	17	9 (52.94)	0 (00.00)	10 (58.82)	24.15 ± 2.49
Middle differentiation	13	2 (15.38)	3 (23.08)	7 (53.85)	27.07 ± 2.53
Low differentiation	17	0 (00.00)1	6 (35.29)2	5 (29.41)	28.03 ± 2.63
Liver infiltration
Positive	18	1 (5.56)	7 (38.89)	6 (33.33)	24.87 ± 2.83
Negative	29	10 (34.48)3	2 (6.90)4	16 (55.17)	26.37 ± 2.45
lymph node metastasis
Positive	20	1 (5.00)	8 (40.00)	5 (25.00)	23.56 ± 2.19
Negative	27	10 (37.04)5	1 (3.70)6	17 (62.96)7	26.67 ± 2.33
TNM stage
I+ II	23	10 (43.48)	0 (00.00)	15 (65.22)	24.15 ± 2.78
III + IV	24	1 (4.17)8	9 (37.50)9	7 (29.17)10	29.84 ± 2.53

¹P < 0.0001;

²P = 0.008 vs differentiation degree;

³P = 0.023;

⁴P = 0.006 vs positive liver infiltration;

⁵P < 0.0001,

⁶P = 0.001,

⁷P = 0.009 vs positive lymph node metastasis;

⁸P = 0.001;

⁹P < 0.0001;

¹⁰P = 0.013 vs TNM stage I+ II.