Relationship between nm23H1 genetic instability and clinical pathological characteristics in Chinese digestive system cancer patients

Table 4 Relationship between clinical pathological parameters and nm23H1 genetic instability in colon cancer

Clinical pathological factors	Cases	MSI+ (%)	LOH+ (%)	nm23H1+ (%)	nm23H1 expression intensity (mean ± SD)
Histological type	30	8 (26.67)	6 (20.00)	16 (53.33)	40.21 ± 3.29
Tubular adenocarcinoma	25	7 (28.00)	5 (20.00)	15 (60.00)	40.76 ± 2.74
High differentiation	8	2 (25.00)	1 (12.50)	8 (100.00)	41.49 ± 2.01
Middle differentiation	13	5 (38.46)	2 (15.38)	6 (46.15)	40.41 ± 1.98
Low differentiation	4	0 (00.00)	2 (50.00)	1 (25.00)1	40.18 ± 2.17
Mucoid adenocarcinoma	5	1 (20.00)	1 (20.00)	1 (20.00)	39.53 ± 2.61
Serosa infiltration
Positive	20	7 (35.00)	3 (15.00)	12 (48.00)	41.02 ± 2.14
Negative	10	1 (10.00)	3 (30.00)	4 (40.00)	41.45 ± 2.23
Lymph node metastasis
Positive	11	1 (9.09)	5 (45.45)	3 (27.27)	39.14 ± 2.34
Negative	19	7 (36.84)	1 (5.26)2	13 (68.42)3	41.75 ± 1.65
TNM stage
I+ II	16	7 (43.75)	1 (11.76)	13 (81.25)	41.49 ± 2.01
III + IV	14	1 (7.14)4	5 (35.71)5	3 (21.43)6	39.53 ± 2.61

¹P = 0.004 vs differentiation degree of tubular adenocarcinoma;

²P = 0.003,

³P = 0.074 vs positive lymph node metastasis;

⁴P = 0.023,

⁵P = 0.046,

⁶P < 0.0001 vs TNM stage I+ II.