Relationship between nm23H1 genetic instability and clinical pathological characteristics in Chinese digestive system cancer patients

Table 1 Relationship between clinical pathological parameters and nm23H1 genetic instability in gastric cancer

Clinical pathological factors	Cases (n)	MSI+ (%)	LOH+ (%)	nm23H1+ (%)	nm23H1 expression intensity (mean ± SD)
Histological type	40	8 (20.00)	7 (17.50)	22 (55.00)	40.63 ± 2.95
Tubular adenocarcinoma	33	7 (22.21)	6 (18.18)	21 (63.64)	41.56 ± 2.78
High differentiation	10	3 (30.00)	1 (10.00)	10 (100.00)	41.83 ± 1.52
Middle differentiation	15	3 (20.00)	2 (13.33)	9 (60.00)	40.69 ± 2.35
Low differentiation	8	1 (12.50)	3 (37.50)	2 (25.00)1	41.43 ± 1.89
Mucoid adenocarcinoma	7	1 (14.29)	1 (14.29)	1 (14.29)2	39.87 ± 2.31
Serosa infiltration
Positive	24	3 (12.50)	6 (25.00)	10 (41.67)	39.76 ± 2.64
Negative	16	5 (31.25)	1 (6.25)	12 (75.00)3	41.45 ± 2.23
Lymph node metastasis
Positive	20	1 (5.00)	6 (30.00)	6 (30.00)	39.14 ± 2.34
Negative	20	7 (35.00)4	1 (5.00)5	16 (80.00)6	41.75 ± 1.65
TNM stage
I+ II	22	7 (31.82)	1 (4.55)	17 (77.27)	41.22 ± 1.87
III + IV	18	1 (5.56)7	6 (33.33)8	5 (17.86)9	40.13 ± 2.35

¹P < 0.0001 vs differentiation degree of tubular adenocarcinoma;

²P = 0.017 vs tubular adenocarcinoma;

³P = 0.039 vs positive serosa infiltration;

⁴P = 0.017,

⁵P = 0.038,

⁶P = 0.001 vs negative lymph node metastasis;

⁷P = 0.04,

⁸P = 0.017,

⁹P = 0.001 vs TNM stage I+ II.