Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma

Table 2 Baseline characteristics according to the methylation profile at the Igf2 locus (U, UM, and M, respectively, for hypomethylated, normal and hypermethylated patterns) in patients with Child-Pugh A hepatitis C-related cirrhosis

	U (n = 13)	UM (n = 64)	M (n = 17)	Asymptotic global P-value
Male gender (%)	7 (53.8%)	38 (59.4%	10 (58.8%)	0.934
Age (yr)	58.15 (16.71)	57.55 (13.00)	57.89 (14.41)	0.985
Alcohol (g/d)	43.08 (64.21)	22.28 (45.97)	38.24 (77.48)	0.551
Tobacco (Pack, yr)	3.8 (7.1)	6.1 (13.1)	5.7 (11.5)	0.981
BMI (kg/m2)	26.32 (5.18)	25.41 (4.97)	23.86 (4.04)	0.244
Diabetes (%)	2 (15.4%)	14 (21.9%)	4 (23.5%)	0.883
Platelets (× 103/mm3)	147.28 (64.46)	152.32 (63.71)	177.30 (127.43)	0.958
Prothrombin (%)	79.46 (17.81)	84.58 (16.59)	85.59 (13.28)	0.433
Albumin (g/L)	40.45 (4.96)	40.77 (6.27)	42.76 (3.40)	0.437
Bilirubin (μmol/L)	14.58 (9.66)	15.16 (8.85)	15.50 (8.45)	0.731
ALAT (× ULN)	3.23 (2.13)	3.23 (2.61)	3.14 (2.16)	0.961
AFP (ng/mL)	13.58 (11.24)	13.88 (18.57)	28.21 (51.52)	0.530
Serum IGF2 (ng/mL)1	249.64 (81.23)	276.32 (116.97)	321.55 (129.24)	0.393
OV grade II or III (%)	5 (38.5%)	9 (14.1%)	2 (11.8%)	0.084
Knodell score (mean, SD)	11.6 (1.8)	10.6 (2.3)	10.7 (2.5)	0.414
HCV genotype 12 (%)	7 (63.6%)	41 (78.8%)	8 (53.3%)	0.125

Quantitative variables are expressed as means (SD). BMI: Body mass index; ALAT: Alanine amino-transferase; ULN: Upper limit of normal; AFP: Alpha-foetoprotein; IGF2: Insulin growth factor 2; OV: Esophageal varices; HCV:hepatitis C virus.

¹Performed in 63 patients,

²known in 78 patients (11, 52, 15 patients respectively in U, UM and M groups).