Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells

Table 7 IC₅₀ and sensitization ratio of vinblastine and its combinations with Rosco towards human colorectal cancer cell lines

Treatment with vinblastine and combinations with Rosco	IC50 (mol/L)			Sensitization ratio1
	SW48	SW1116	SW837	SW48	SW1116	SW837
Vinb.	1 × 10-8	6.3 × 10-7	4.2 × 10-7	-	-	-
Vinb. + 5 μg/mL Rosco	5.4 × 10-11	7.5 × 10-8	5.0 × 10-8	1.9 × 102	8.4	8.4
Vinb. + 10 μg/mL Rosco	5.4 × 10-11	7.9 × 10-10	4.6 × 10-10	1.9 × 102	8.0 × 102	9.1 × 102

¹Sensitization ratio = IC₅₀ (Vinb.)/IC₅₀ (Vinb. + Rosco).