Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells

Table 5 IC₅₀ and sensitization ratio of doxorubicin and combinations with Rosco towards human colorectal cancer cell lines

Treatment with doxorubicin and its combinations with Rosco	IC50 (mol/L)			Sensitization ratio1
	SW48	SW1116	SW837	SW48	SW1116	SW837
Dox.	5.4 × 10-8	6 × 10-7	4.1 × 10-7	-	-	-
Dox. + 5 μg/mL Rosco	5.8 × 10-11	2 × 10-7	4.1 × 10-8	9.3 × 102	3	10
Dox. + 10 μg/mL Rosco	5.8 × 10-11	4.5 × 10-9	8.2 × 10-10	9.3 × 102	1.3 × 102	5.0 × 102

¹Sensitization ratio = IC₅₀ (Dox.)/IC₅₀ (Dox. + Rosco).