Roscovitine synergizes with conventional chemo-therapeutic drugs to induce efficient apoptosis of human colorectal cancer cells

Table 1 IC₅₀ and sensitization ratio of taxol and its combinations with Rosco towards human colorectal cancer cell lines

Treatment with taxol and combinations with Rosco	IC50 (mol/L)			Sensitization ratio1
	SW48	SW1116	SW837	SW48	SW1116	SW837
Taxol	4.8 × 10-8	1.2 × 10-7	3.8 × 10-7	-	-	-
Taxol + 5 μg/mL Rosco	7.4 × 10-10	1.0 × 10-8	5.4 × 10-8	65	12	7
Taxol + 10 μg/mL Rosco	7.5 × 10-11	8.1 × 10-10	6.7 × 10-10	6.4 × 102	1.5 × 102	5.7 × 102

¹Sensitization ratio = IC₅₀ (taxol)/IC₅₀ (taxol + Rosco).