Relationship between microvessel count and post-hepatectomy survival in patients with hepatocellular carcinoma

Table 5 Multivariate analysis by Cox’s proportional hazard test of prognostic factors influencing disease-free survival and overall survival in HCC after hepatectomy

	Disease-free survival			Overall survival
	Risk ratio	95% CI	P	Risk ratio	95% CI	P
Number ≥ 2 lesions	2.28	1.44-3.60	0.0004	1.87	1.08-3.24	0.025
Vessel involvement positive	2.04	1.28-3.24	0.003	2.07	1.16-3.68	0.014
Macroscopic finding SNEG or CMN	1.43	0.89-2.29	0.135	2.33	1.17-4.66	0.017
Surgical margin positive	1.75	0.93-3.33	0.086	1.59	0.65-3.91	0.310
Blood loss > 1500 mL	1.36	0.81-2.29	0.135	1.50	0.82-2.74	0.189
Liver damage grade B	1.99	1.20-3.31	0.007	1.44	0.77-2.69	0.255
PIVKA-II > 400 mAU/mL	1.30	0.81-2.13	0.274	1.15	0.65-2.04	0.636
Microvessel count ≤ 178/mm2	1.64	1.06-2.50	0.024	1.35	0.71-2.04	0.266

Macroscopic classification by Liver Cancer Study Group of Japan[19]. SN: Single nodular; SNEG: Single nodular with extranodular growth; CMN: Confluent multinodular group; CI: Confidence interval.