Prevention of hepatotoxicity due to anti tuberculosis treatment: A novel integrative approach

Table 4 Effects of herbal formulation on incidence, onset, duration and severity of hepatitis

ATT induced hepatitis outcome (Table 2)	Control (n = 192)	Trial (n = 316)	P
Patients with raised AST (%)	27 (14)	2 (0.63)	< 0.0001
Patients with raised S bilirubin (%)	17/27 (63)	0	< 0.0001
Mean onset of hepatitis symptomatic	49.12 ± 17.22	-	< 0.0001
Mean onset of hepatitis asymptomatic	29.9 ± 17.63	39 ± 11.31	0.443
Mean onset of any hepatitis	42 ± 19.48	39 ± 11.31	0.776
Mean duration of raised AST	27.5 ± 7.25	21	< 0.0001
Hepatitis gradation
Grade-I	10	2	< 0.0001
Grade-II	9	0	< 0.0001
Grade-III	8	0	< 0.0001
Grade-IV	0	0
Reinstitution of ATT in patients (%)	22/27 (81.5)	NA

P calculated by χ² (categorical data) and two-sided Student’s t-test with Welch’s procedure (continuous data with unequal variance). NA: Not applicable.