Inhibition of hepatitis B virus gene expression and replication by artificial microRNA

Figure 2 A: Effect of amiRNA-HBV on HBsAg levels; B: Effect of amiRNA-HBV on HBeAg levels. HBsAg and HBeAg levels are expressed as mean ± SD. Compared with negative control, all three plasmids had significant inhibitory effect on HBsAg and HBeAg at 72 h and 96 h after transfection (HBsAg: P = 0.00039 and 0.0012 for S89 group, P = 0.000011 and 0.00021 for S367 group, P = 0.000016 and 0.000056 for S608 group; HBeAg: P = 0.02 and 0.035 for S89 group, P = 0.0093 and 0.0032 for S367 group, P = 0.007 and 0.0025 for S608 group).