Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocellular carcinoma

doi:10.3748/wjg.14.4633

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Aug 7, 2008 (publication date) through Jul 22, 2024

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World Journal of Gastroenterology

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1007-9327

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Liver Cancer

World J Gastroenterol. Aug 7, 2008; 14(29): 4633-4642
Published online Aug 7, 2008. doi: 10.3748/wjg.14.4633

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Figure 5 MAT II enzyme activity was gradually decreased from 1 d to 5 d in a time-dependent manner after transfected with LV-shMAT2B, but remained relatively unchanged in cells treated with siRNAs. In human cancer cells Bel-7402 and HepG2 (A), Hepatic SAM level in the two HCC cells were increased by LV-shMAT2B in a time-dependent manner, but remained relatively unchanged in cells treated with siRNAs (B).

Citation: Wang Q, Liu QY, Liu ZS, Qian Q, Sun Q, Pan DY. Lentivirus mediated shRNA interference targeting MAT2B induces growth-inhibition and apoptosis in hepatocellular carcinoma. World J Gastroenterol 2008; 14(29): 4633-4642
URL: https://www.wjgnet.com/1007-9327/full/v14/i29/4633.htm
DOI: https://dx.doi.org/10.3748/wjg.14.4633