Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk

Table 4 Allelic odds ratios and 95% confidence intervals for comparison of TNF-α variants with IBD status in New Zealand IBD patients and Caucasians

	TNF-α_361525 (-238 G/A)				TNF-α_1799724 (-857C/T)				TNF-α_1800629 (-308 G/A)
	CD		UC		CD		UC		Crohn's		UC
	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI	OR	95% CI
Female	1.00	0.59-1.69	0.64	0.35-1.18	1.06	0.65-1.74	1.07	0.64-1.79	1.01	0.72-1.41	1.19	0.85-1.67
Male	1.29	0.69-2.41	1.15	0.63-2.08	1.08	0.62-1.89	1.46	0.84-2.53	1.26	0.85-1.87	1.34	0.93-1.93
Age at first diagnosis
0-16 yr	1.30	0.54-3.14	0.31	0.04-2.29	1.67	0.51-5.48	0.8	0.28-2.31	1.66	0.97-2.85	1.60	0.83-3.07
17-40 yr	0.92	0.55-1.54	0.8	0.46-1.39	0.85	0.53-1.36	0.75	0.47-1.20	1.01	0.74-1.39	1.23	0.90-1.68
> 40 yr	1.30	0.78-2.17	1.02	0.62-1.69	0.72	0.44-1.18	1.31	0.76-2.25	1.08	0.77-1.52	1.26	0.93-1.71
CD location
Ileal	0.93	0.51-1.71			0.98	0.55-1.75			1.00	0.69-1.45
Colonic	1.09	0.65-1.83			1.00	0.59-1.69			1.25	0.91-1.72
Ileocolonic	1.44	0.79-2.63			0.56	0.32-0.97			0.92	0.59-1.42
UC location
Proctitis			1.07	0.61-1.87			0.68	0.41-1.12			0.90	0.62-1.30
Left colon			0.76	0.38-1.52			1.36	0.68-2.73			0.97	0.65-1.45
Pancolitis			0.74	0.40-1.36			1.08	0.62-1.88			1.91	1.41-2.60
CD Behaviour
Inflammatory	1.27	0.81-2.00			1.05	0.64-1.71			1.19	0.89-1.60
Structuring	1.19	0.67-2.10			0.66	0.39-1.11			1.01	0.69-1.47
Penetrating	0.16	0.02-1.17			0.65	0.31-1.37			0.89	0.50-1.59
Ileal/Structuring	1.34	0.70-2.58			0.95	0.47-1.92			1.04	0.66-1.64
Colonic/Inflammatory	1.29	0.77-2.17			1.06	0.60-1.87			1.29	0.92-1.80
	TNF-α_361525 (-238 G/A)				TNF-α_1799724 (-857C/T)				TNF-α_1800629 (-308 G/A)
Any relative with IBD	1.15	0.57-2.32	0.89	0.39-2.01	1.02	0.49-2.12	1.02	0.47-2.20	1.49	0.98-2.27	0.98	0.60-1.60
Bowel resection	1.12	0.65-1.93	0.7	0.29-1.66	0.59	0.37-0.95	0.97	0.47-2.02	0.93	0.65-1.34	1.57	1.02-2.41
Smoker at diagnosis	1.04	0.54-1.99	0.66	0.23-1.87	1.00	0.52-1.91	0.48	0.25-0.94	0.84	0.54-1.30	1.08	0.63-1.86
Ever used immunomodulators	1.07	0.66-1.75	0.66	0.29-1.48	0.93	0.57-1.51	0.75	0.41-1.39	1.09	0.80-1.48	1.46	0.98-2.17
Any EIMs	1.11	0.55-2.24	0.5	0.18-1.41	1.60	0.67-3.80	2.07	0.74-5.83	1.46	0.96-2.22	1.28	0.81-2.03