Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk

Table 3 Genotype and allele counts for TNF-α variants in New Zealand IBD patients and Caucasians

SNP	Controls	CD	UC	CD + UC	IC
TNF-α -238 G/A
AA	0	2 (0.5)	2 (0.5)	4 (0.5)	0
AG	50 (12.1)	47 (12.1)	39 (9.6)	86 (10.9)	2 (7.4)
GG	365 (87.9)	338 (87.3)	364 (89.9)	702 (88.6)	25 (92.6)
Genotype P		0.51	0.19	0.37
HWE P	0.38	0.68	0.31	0.35	1
A	50 (6.0)	51 (6.6)	43 (5.3)	94 (5.9)	2 (3.7)
G	780 (94.0)	723 (93.4)	767 (94.7)	1490 (94.1)	52 (96.3)
OR (95%CI)		1.10 (0.72, 1.68)	0.87 (0.56, 1.36)	0.98 (0.68, 1.42)
Allelic P		0.64	0.53	0.93
TNF-α -308 G/A
AA	10 (2.4)	16 (4.1)	23 (5.7)	39 (4.9)	1 (4.0)
AG	123 (29.7)	112 (28.9)	122 (30.3)	234 (29.6)	4 (16.0)
GG	282 (67.9)	260 (67.0)	258 (64.0)	518 (65.5)	20 (80.0)
Genotype P		0.41	0.049	0.1
HWE P	0.49	0.4	0.1	0.07	0.29
A	143 (17.2)	144 (18.6)	168 (20.8)	312 (19.7)	6 (12.0)
G	687 (82.8)	632 (81.4)	638 (79.2)	1270 (80.3)	44 (88.0)
OR (95% CI)		1.09 (0.84, 1.42)	1.27 (0.98, 1.63)	1.18 (0.94, 1.48)
Allelic P		0.49	0.06	0.14
TNF-α -857C/T
CC	359 (88.2)	332 (86.0)	358 (88.4)	690 (87.2)	21 (77.8)
CT	45 (11.1)	51 (13.2)	41 (10.1)	92 (11.6)	6 (22.2)
TT	3 (0.7)	3 (0.8)	6 (1.5)	9 (1.1)	0
Genotype P		0.61	0.57	0.85
HWE P	0.2	0.45	0.004	0.01	1
C	763 (93.7)	715 (92.6)	757 (93.5)	1472 (93.0)	48 (88.9)
T	51 (6.3)	57 (7.4)	53 (6.5)	110 (7.0)	6 (11.1)
OR (95% CI)		0.84 (0.56,1.26)	0.95 (0.63,1.45)	0.89 (0.63,1.28)
Allelic P		0.38	0.82	0.52