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©2008 The WJG Press and Baishideng.
World J Gastroenterol. Aug 7, 2008; 14(29): 4652-4661
Published online Aug 7, 2008. doi: 10.3748/wjg.14.4652
Published online Aug 7, 2008. doi: 10.3748/wjg.14.4652
Table 1 Summary of clinical and demographic data on Caucasian IBD patients genotyped for at least one TNF-α polymorphism n (%)
| CD | UC | IC | |
| Gender | 388 | 405 | 27 |
| Female | 249 (64.2) | 214 (52.8) | 15 (55.6) |
| Male | 139 (35.8) | 191 (47.2) | 12 (44.4) |
| Age at first diagnosis | |||
| Below 17 | 39 (10.0) | 26 (6.4) | 0 |
| Between 17 and 40 | 199 (51.3) | 184 (45.4) | 15 (55.6) |
| Above 40 | 150 (38.7) | 195 (48.2) | 12 (44.4) |
| CD location | |||
| Ileal | 125 (32.2) | ||
| Colonic | 169 (43.6) | ||
| Ileocolonic | 90 (23.2) | ||
| Unknown (U + UN) | 4 (1.0) | ||
| UC location | |||
| Proctitis | 140 (34.6) | 3 (11.1) | |
| Left colon | 107 (26.4) | 5 (18.5) | |
| Pancolitis | 154 (38.0) | 19 (70.4) | |
| Unknown | 4 (1.0) | 0 | |
| Behaviour | |||
| Non-structuring, non-penetrating perianal disease: With | 47 (21.5) | ||
| Without | 172 (78.5) | ||
| Structuring perianal disease: With | 46 (38.0) | ||
| Without | 75 (62.0) | ||
| Penetrating perianal disease: With | 17 (35.4) | ||
| Without | 31 (64.6) | ||
| Any relative with IBD: Yes (n = 143) | 74 (19.1) | 65 (16.1) | 5 (18.5) |
| Bowel resection: Yes (n = 214) | 142 (36.6) | 70 (17.3) | 2 (7.4) |
| Smoker at diagnosis: Yes (n = 147) | 97 (25.7) | 49 (12.3) | 2 (7.7) |
| Ever used immunomo- dulators: Yes (n = 296) | 203 (52.3) | 86 (21.2) | 8 (29.6) |
| Extra intestinal manifestations: Yes (n = 142) | 75 (19.3) | 64 (15.8) | 3 (11.1 |
- Citation: Ferguson LR, Huebner C, Petermann I, Gearry RB, Barclay ML, Demmers P, McCulloch A, Han DY. Single nucleotide polymorphism in the tumor necrosis factor-alpha gene affects inflammatory bowel diseases risk. World J Gastroenterol 2008; 14(29): 4652-4661
- URL: https://www.wjgnet.com/1007-9327/full/v14/i29/4652.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.4652