Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy

Table 7 Logistic regression analysis

Genes	P	OR	95% CI
CARD15	2.34E-14	2.908	2.211-3.825
ATG	0.008	1.442	1.099-1.894
ATG (adj CARD15)	0.014	1.439	1.077-1.924
ATG* CARD15	0.692	0.851	0.382-1.894
IL23	0.005	0.613	0.435-0.863
IL23 (adj CARD15)	0.029	0.629	0.414-0.954
IL23* CARD15	0.981	1.010	0.432-2.360
OCTN	0.028	1.434	1.039-1.980
OCTN (adj CARD15)	0.021	1.479	1.061-2.061
TTCC* CARD15	0.632	0.821	0.367-1.839
ATG*IL23*OCTN*CARD15	0.428	0.651	0.226-1.880

Individual contribution of CARD15 (at least 1 variant), ATG16L1 (GG/AG vs AA), IL23R rs11209026 (AG/AA vs GG), and OCTN dyploype (TTCC) to risk CD. adj CARD15: Contribution from the term after adjustment for CARD15 genotype.