Copyright
©2008 The WJG Press and Baishideng.
World J Gastroenterol. Aug 7, 2008; 14(29): 4643-4651
Published online Aug 7, 2008. doi: 10.3748/wjg.14.4643
Published online Aug 7, 2008. doi: 10.3748/wjg.14.4643
Table 6 Genotype and allele frequencies of ATG16L1 and IL23R SNPs in UC cases stratified by phenotypic subgroups, (n)
SNP/gene genotype | rs2241880 ATG16L1 | rs7517847 IL23R | rs11209026 IL23R | ||||||||||||
AA (141) | AG (315) | GG (212) | Total (668) | Freq (G) 0.553 | GG (88) | GT (390) | TT (326) | Total (804) | Freq (G) 0.352 | AA (1) | AG (72) | GG (750) | Total (823) | Freq (A) 0.045 | |
Sex | |||||||||||||||
Male | 77 | 183 | 112 | 372 | 0.547 | 41 | 236 | 185 | 462 | 0.344 | 0 | 45 | 432 | 477 | 0.047 |
Female | 64 | 132 | 100 | 296 | 0.561 | 47 | 154 | 141 | 342 | 0.363 | 1 | 27 | 318 | 346 | 0.042 |
Age at diagnosis (yr) | |||||||||||||||
≤ 16 (A1) | 30 | 58 | 48 | 136 | 0.566 | 15 | 76 | 49 | 140 | 0.379 | 0 | 11 | 129 | 140 | 0.039 |
17-40 (A2) | 79 | 159 | 102 | 340 | 0.534 | 40 | 213 | 170 | 423 | 0.346 | 0 | 33 | 401 | 434 | 0.038 |
> 40 (A3) | 24 | 84 | 55 | 163 | 0.595 | 28 | 86 | 89 | 203 | 0.350 | 1 | 25 | 184 | 210 | 0.064 |
Disease localization | |||||||||||||||
Rectum | 18 | 41 | 15 | 74 | 0.480 | 13 | 38 | 39 | 90 | 0.356 | 1 | 8 | 80 | 89 | 0.056 |
Rectum-sigmoid | 20 | 55 | 39 | 114 | 0.583 | 20 | 82 | 46 | 148 | 0.412 | 0 | 21 | 134 | 155 | 0.068 |
Left colon | 41 | 101 | 64 | 206 | 0.556 | 27 | 104 | 100 | 231 | 0.342 | 0 | 19 | 215 | 234 | 0.041 |
Colon | 54 | 104 | 86 | 244 | 0.566 | 24 | 148 | 124 | 296 | 0.331 | 0 | 22 | 283 | 305 | 0.036 |
Perianal disease | |||||||||||||||
Yes | 3 | 3 | 6 | 12 | 0.625 | 0 | 6 | 8 | 14 | 0.214 | 0 | 2 | 13 | 15 | 0.067 |
No | 129 | 298 | 198 | 625 | 0.555 | 82 | 367 | 301 | 750 | 0.354 | 1 | 67 | 699 | 767 | 0.045 |
Smoking history | |||||||||||||||
No | 81 | 173 | 125 | 379 | 0.558 | 51 | 203 | 185 | 439 | 0.347 | 1 | 38 | 408 | 447 | 0.045 |
Yes | 25 | 54 | 25 | 104 | 0.500 | 10 | 65 | 41 | 116 | 0.366 | 0 | 12 | 104 | 116 | 0.052 |
Ex | 25 | 72 | 51 | 148 | 0.588 | 20 | 105 | 77 | 202 | 0.359 | 0 | 18 | 191 | 209 | 0.043 |
Surgery | |||||||||||||||
Yes | 11 | 33 | 26 | 70 | 0.607 | 9 | 37 | 35 | 81 | 0.340 | 0 | 9 | 74 | 83 | 0.054 |
No | 122 | 268 | 178 | 568 | 0.549 | 74 | 337 | 274 | 685 | 0.354 | 1 | 61 | 638 | 700 | 0.045 |
-
Citation: Latiano A, Palmieri O, Valvano MR, D’Incà R, Cucchiara S, Riegler G, Staiano AM, Ardizzone S, Accomando S, Angelis GL, Corritore G, Bossa F, Annese V. Replication of
interleukin 23 receptor andautophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy. World J Gastroenterol 2008; 14(29): 4643-4651 - URL: https://www.wjgnet.com/1007-9327/full/v14/i29/4643.htm
- DOI: https://dx.doi.org/10.3748/wjg.14.4643