Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy

Table 2 Genotypes and alleles distribution for ATG16L1 and IL23R SNPS in CD, UC and controls

	Genotypes							Alleles
	AA	Aa	aa	Total	P	OR (95% CI)		Freq	P	OR (95% CI)
ATG16L1
rs2241880					(AA Aa vs aa)		G
CD Total	227 (34%)	335 (50%)	105 (16%)	667	0.008	1.44 (1.10-1.89)		0.59	0.003	1.25 (1.08-1.45)
CD adult	165 (34%)	254 (52%)	72 (15%)	491	0.004	1.57 (1.16-2.13)		0.59	0.004	1.27 (1.08-1.49)
CD pediatric	62 (35%)	81 (46%)	33 (19%)	176	0.466	1.17 (0.77-1.77)		0.58	0.122	1.20 (0.95-1.52)
UC Total	212 (32%)	315 (47%)	141 (21%)	668	0.956	1.01 (0.78-1.30)		0.55	0.381	1.07 (0.92-1.24)
UC adult	157 (31%)	244 (48%)	105 (21%)	506	0.839	1.03 (0.78-1.36)		0.55	0.469	1.06 (0.90-1.25)
UC pediatric	55 (34%)	71 (44%)	36 (22%)	162	0.779	0.94 (0.63-1.42)		0.56	0.473	1.09 (0.86-1.39)
Controls	214 (29%)	376 (50%)	159 (21%)	749	-			0.54
IL23R
rs7517847					(Aa aa vs AA)		G
CD Total	366 (51%)	305 (42%)	52 (7%)	723	< 0.01	0.63 (0.51-0.77)		0.28	< 0.01	0.64 (0.55-0.75)
CD adult	273 (51%)	225 (42%)	42 (8%)	540	< 0.01	0.63 (0.50-0.79)		0.29	< 0.01	0.65 (0.55-0.78)
CD pediatric	93 (51%)	80 (44%)	10 (5%)	183	< 0.01	0.62 (0.45-0.86)		0.27	< 0.01	0.61 (0.48-0.79)
UC Total	326 (41%)	390 (49%)	88 (11%)	804	0.567	0.94 (0.77-1.16)		0.35	0.111	0.89 (0.76-1.03)
UC adult	259 (41%)	301 (48%)	71 (11%)	631	0.468	0.92 (0.74-1.15)		0.35	0.121	0.88 (0.75-1.03)
UC pediatric	67 (39%)	89 (51%)	17 (10%)	173	0.927	1.02 (0.72-1.43)		0.36	0.400	0.90 (0.70-1.15)
Controls	280 (39%)	328 (46%)	108 (15%)	716	-			0.38
rs11209026							A
CD Total	675 (92%)	60 (8%)	0 (0%)	735	0.005	0.61 (0.43-0.86)		0.04	0.005	0.62 (0.45-0.87)
CD adult	502 (91%)	50 (9%)	0 (0%)	552	0.042	0.69 (0.48-0.99)		0.05	0.041	0.69 (0.49-0.99)
CD pediatric	173 (95%)	10 (5%)	0 (0%)	183	0.006	0.40 (0.20-0.78)		0.03	0.007	0.41 (0.21-0.80)
UC Total	750 (91%)	72 (9%)	1 (0%)	823	0.015	0.67 (0.48 - 0.93)		0.04	0.019	0.69 (0.50-0.94)
UC adult	589 (91%)	58 (9%)	1(0%)	648	0.035	0.69 (0.49-0.98)		0.05	0.043	0.71 (0.51-0.99)
UC pediatric	161 (92%)	14 (8%)	0 (0%)	175	0.085	0.60 (0.33-1.08)		0.04	0.087	0.61 (0.34-1.08)
Controls	634 (87%)	91 (13%)	1 (0%)	726	-			0.06

“A” refers to wild type and “a” to mutated allele. Adult and pediatric subgroups are divided on the basis of the age at diagnosis (≥ 19 years and < 19 years, respectively).