Replication of interleukin 23 receptor and autophagy-related 16-like 1 association in adult- and pediatric-onset inflammatory bowel disease in Italy

Table 1 Demographic and clinical features of CD and UC according to the Montreal classification[39]

	CD (n = 763)	UC (n = 843)
Sex (M/F)	435/328	492/351
Duration of follow-up, mean ± SD (range)	8 ± 7 (1-37)	9 ± 7 (1-41)
Age at diagnosis (yr), mean ± SD (range)	29 ± 15 (1-79)	32 ± 16 (1-76)
≤ 16 (A1)	173 (22%)	155 (18%)
17-40 (A2)	431 (57%)	458 (55%)
> 40 (A3)	159 (21%)	230 (27%)
Disease localization CD, n (%)
Ileum (L1 ± L4)	241 (31%)
Colon (L2 ± L4)	200 (26%)
Ileo-colon (L3 ± L4)	315 (41%)
Upper GI (L4)	7 (2%)
Disease extent UC, n (%)
Rectum (E1)		102 (13%)
Left colon (E2)		416 (49%)
Pancolitis (E3)		325 (38%)
Disease behavior CD, n (%)
Inflammatory (B1 ± p)	346 (46%)
Stricturing (B2 ± p)	177 (23%)
Penetrating (B3 ± p)	240 (31%)
Perianal disease y/n (%)	137/626 (18%)	17/826 (2%)
Smoking history
Yes	242 (33%)	119 (15%)
No	423 (55%)	510 (60%)
Ex	98 (12%)	214 (25%)
Family history of IBD y/n (%)	74/689 (10%)	53/790 (6%)
Surgery y/n, n (%)	237/526 (31%)	95/748 (13%)
Extra-intestinal manifestations y/n (%)	304/459 (40%)	182/661 (21%)