Chronic liver disease in Aboriginal North Americans

Table 2 Major causes of viral hepatitis in Aboriginal North Americans

Aboriginal group	Study populations	Hepatitis A	Hepatitis B	Hepatitis C	Comments
Native Americans	South Dakota NA Navajo NA Urban and Veterans populations	Pre-vaccine incidence was 96/100 000 Seroprevalence: 76%	N/A	Seroprevalence range: 3%-32%	Hepatitis A incidence now is comparable to general population: 1.0-2.0/100 000
Alaska Natives	Random distribution of AN tribes	49% seroprevalance pre-vaccination	6% sAg+, 24% core IgG+	0.8% seroprevalance	Heavy burden of hepatitis a prior to vaccination. Hepatitis B endemic to AN with high rates of HCC in certain regions, vaccination has lead to decreased incidence
First Nations (Canada)	Manitoba FN British Columbia FN Inuit	Seroprevalence of 90% in those < 40 yr; 31/100 000 incidence pre-vaccine	5% sAg+, 27% core IgG+ in circumpolar regions, much lower outside circumpolar areas	1.1% seroprevalence in Inuit, 2%-20% in non-Inuit	Similar patterns of hepatitis as seen in US.
Native Greenlanders (Inuit)	Inuit	54% seroprevalence	7%-12% sAg+, 42% core IgG+	< 1% seroprevalence	Hepatitis B may be spread sexually more frequently than other Aboriginal populations. HCC also less common