Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease

Table 3 Genotype-phenotype correlations in CD patients

Total CD patients (n = 133)	CARD15 no risk alleles (n = 68, 51.1%)	R702W 1 risk allele (n = 26, 19.6%)	G908R 1 risk allele (n = 13, 9.7%)	L1007finsC 1 risk allele (n = 26, 19.6%)	CARD15 at least 1 risk allele (n = 65, 48.8%)	CARD15 compound heterozygous (n = 48, 36.1%)
Age (mean ± SD)	41.5 ± 11.2	41.2 ± 11.9	43.02 ± 10.9	42.0 ± 12.8	42.3 ± 12.1	42.7 ± 11.9
Sex (m/f, 70/63)	32/36	13/13	8/5	10/16	30/35	25/23
Localization (%)
Ileum (n = 61)	25 (36.8)	11 (42.3)	4 (30.8)	21 (80.7)	38 (58.5)	30 (62.5)
Ileo-colon (n = 39)	22 (32.3)	10 (38.5)	4 (30.8)	3 (11.5)	15 (23.0)	10 (20.8)
Colon (n = 30)	18 (26.5)	5 (19.5)	5 (38.4)	2 (7.8)	12 (18.5)	8 (16.7)
Upper GI (n = 3)	3 (4.4%)				0	0
P		> 0.051	> 0.051	0.0011	0.042	0.033
Disease type (%)
Inflammatory (n = 37)	14 (20.6)	7 (27.0)	6 (46.0)	10 (38.5)	23 (35.4)	8 (16.6)
Stenosing (n = 56)	32 (47.0)	11 (42.3)	7 (54.0)	6 (23.0)	24 (37.0)	34 (70.8)
Fistulizing (n = 40)	22 (32.4)	8 (30.7)	0	10 (38.5)	18 (27.6)	6 (12.6)
P		> 0.051	0.031	> 0.051	> 0.052	0.023
Resective Surgery (%)	18 (26.4)	9 (34.6)	9 (69.2)	14 (53.9)	32 (49.2)	31 (64.6)
P		> 0.051	0.0031	0.011	0.012	0.0003
Extraintestinal manifestations (n = 18, %)	10 (55.5)	3 (11.5)	1 (7.7)	4 (15.3)	8 (13.3)	3 (6.2)

No patients homozygous for R702W, G908R and L1007finsC SNPs were found in this study population.

¹CD patients no risk allele vs CD patients with risk allele;

²CARD15 at least 1 risk allele vs CD patients no risk allele;

³CARD15 compound heterozygous vs CD patients no risk allele.