Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease

Table 2 NOD2/CARD15 and TLR4 SNPs allele frequencies of CD patients vs control group and UC patients

Polymorphisms of NOD2/CARD15 and TLR4 genes	CD (n = 133)	Allele frequency (%)	Controls (n = 103)	Allele frequency (%)	1P	OR (95% CI)	UC (n = 45)	Allele frequency (%)	2P	OR (95% CI)
R702W
Wild-type	107 (80.4%)	9.8	98 (95.1%)	2.4	0.001	4.09 (1.5-11.9)	43 (95.5%)	2.3	0.03	4.49 (1.02-19.8)
Heterozygous	26 (19.6%)		5 (4.9%)				2 (4.5%)
G908R
Wild-type	120 (90.2%)	4.5	94 (91.2%)	4.3	NS	1.01 (0.3-3.5)	41 (91.1%)	4.4	NS	0.90 (0.28-2.92)
Heterozygous	13 (9.8%)		9 (8.8%)				4 (8.9%)
L1007finsC
Wild-type	107 (80.4%)	9.8	97 (94.1%)	2.9	0.002	3.92 (1.55-9.95)	43 (95.5%)	2.3	0.01	5.22 (1.19-22.98)
Heterozygous	26 (19.6%)		6 (5.9%)				2 (4.5%)
D299G
Wild-type	123 (92.5%)	3.7	95 (92.2%)	3.9%	NS	0.96 (0.37-2.54)	42 (93.3%)	3.4	NS	0.87 (0.23-3.35)
Heterozygous	10 (7.5%)		8 (7.8%)				3 (6.7 %)
T399I
Wild-type	125 (94%)	3.0	97 (94.1%)	2.9%	NS	1.15 (0.28-4.64)	42 (93.3%)	3.4	NS	1.11 (0.28-4.40)
Heterozygous	8 (6.0%)		6 (5.9%)				3 (6.7%)

No patients homozygous for NOD2/CARD15 gene R702W, G908R and L1007finsC SNPs were found in this study population; No patients homozygous for TLR4 gene D299G and T399I SNPs were found in this study population.

¹CD patients vs control group;

²CD patients vs UC patients. NS: No significance.