Univariate and multivariate analysis of risk factors for severe clostridium difficile-associated diarrhoea: Importance of co-morbidity and serum C-reactive protein

Table 3 Multivariate analysis of possible risk factors for severe CDAD

	P	OR; 95% CI
Variable (unit)
Charlson’s score (points; 1-point increments)	< 0.05	1.39; 1.06-1.83
Body temperature ≥ 38°C		1.15; 0.35-3.83
Immunosuppressive therapy		1.84; 0.45-7.49
Acid-suppressive therapy		1.28; 0.39-4.21
Opioid use		2.50; 0.80-7.84
Laxative use		2.66; 0.79-8.97
C-reactive protein (mg/L; 10 mg/L increments)	< 0.01	11.2; 10.3-12.1
White blood cell count (G/L; 1 G/L increments)		1.01; 0.96-1.06
Creatinine level (mg/L; 10 mg/L increments)		12.5; 9.2-16.8
Reduced Model
Charlson’s score (points; 1-point increments)	< 0.05	1.29; 1.02-1.61
C-reactive protein (mg/L; 10 mg/L increments)	< 0.001	1.15; 1.08-1.22